November 2019 - Volume 1, Issue 1
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Volume 1, Issue 1
Volume 1, Issue 1

Stein discusses low levels of endocannabinoids found in children with autism spectrum disorder (ASD). Gaillard describes a case of high-CBD and low-THC treatment for ASD. Kakar reviews dosing strategies for medical cannabis.

TABLE OF CONTENTS

In this Issue

Letter From the Editor
Letter From Editor, November 2019
Welcome to the American Journal of Endocannabinoid Medicine. Despite one-third of people in the United States living in a state where they can easily purchase cannabis products, awareness of the effects of various cannabis preparations and the endocannabinoid system is lacking among health care professionals. 
Original Research
Next Generation of Liposomal Delivery for Cannabidiol From a Hemp Extract: A Safety Study
A human clinical safety study examined the alterations in the blood profiles of 10 healthy adults before and after taking CELLg8™ Hemp—an advanced liposomal cannabinoid preparation standardized for cannabidiol—daily for 30 days.
Atypical Presentation of Cannabinoid Hyperemesis Syndrome: Two Case Reports
The following cases describe atypical presentations of cannabinoid hyperemesis syndrome, or a similar phenomenon, in patients using herbal cannabis to treat chronic pain under medical supervision.
Cannabidiol in the Management of Comorbid Rheumatoid Arthritis, Lupus, and Raynaud’s Disease
Cannabis in the News
Cannabis Curricula: Two Universities Pave the Way in Graduate-Level Education
As medical cannabis policy in the United States continues to rapidly evolve, medical education struggles to catch up to legislation. To address these disparities, 2 universities are leading the way in developing graduate-level programs on medical cannabis.
An Update on Vaping Safety
Millions of people regularly vape cannabis products. It may not be propylene glycol on the hot seat this time, but rather additives flowing through cheap devices that can heat over 900°C. The legal and unregulated markets are flooded with inexpensive, disposable hardware, which can heat material well above the vaporizing threshold; in fact, many “vape pens” are not vaporizers—they burn the material.
Cannabis Policy
Cannabis, Health Care, and Federal Law 
Health care professionals are in the unique and difficult  position of being increasingly pressed to give guidance  about cannabis at a time when it is challenging to identify  reliable information.
Clinical Distillation
Book Review: Cannabis sativa L.: Botany and Biotechnology 
Jahan Marcu, PhD, reviews Cannabis sativa L. : Botany and Biotechnology, edited by Suman Chandra, Hemant Lata, and Mahmoud A. ElSohly. Springer. http://doi.org/10.1007/978-3-319- 54564-6_3. Hardcover 479 pages ISBN 978-3-319-54563-9. for HerbalEGram.
Dosing Strategies for Medical Cannabis
A commentary on MacCallum CA, et al. Practical considerations in medical cannabis administration and dosing. Eur J Intern Med. 2018;49:12-19.
Effects of Cannabis Use on Sexual Function in Women 
A commentary on Lynn et al. “The Relationship Between Marijuana Use Prior to Sex and Sexual Function in Women.” Sex Med. 2019;7(2):192-197. 
Low Levels of Endocannabinoids Found in Children With Autism
A commentary on Aran et al. Lower circulating endocannabinoid levels in children with autism spectrum disorder. Mol Autism. 2019;10:2.
Medical Cannabis Intervention Improves Symptoms, Quality of Life Among Skilled Nursing Home Residents
A commentary on Palace ZJ et al. Medical cannabis in the skilled nursing facility: a novel approach to improving symptom management and quality of life. J Am Med Dir Assoc. 2019;20(1):94-98.
The Biochemical System Controlling the Effects of Cannabis: An Introduction
Jahan Marcu, PhD, presents his 2015 article on the endocannabinoid system as it appeared in HerbalEGram. 2015;12(6).
Editorial
A History of Cannabis Use in Women’s Health 
The long history of cannabis in women’s medicine supports further study.
Association Is Not Causation in Cannabis Research
“There is no research on cannabis” is a myth conception frequently encountered. Yet, while stating there is no research on cannabis, many sources are still willing to infer causality and contend that cannabis is both the cause of and answer to various health problems. 
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